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    Carrick Research Group

    Carrick Research Group 2024

     

    • Dr. Carrick

      Jesse Carrick Picture

      Jesse D. Carrick, Ph.D.

      Professor
      Department of Chemistry
      TN Tech University
      Campus Box 5055
      803 Stadium Dr.
      Lab Science Commons, Rm 3304
      Cookeville, TN 38505-0001

      P:  (931) 372-6199
      E:  jcarrick@tntech.edu

      Education

      • A.S. 2000 Motlow State Community College
      • B.S. 2002 Middle TN State University (Prof. Norma K. Dunlap)
      • M.S. 2005 Indiana University-Bloomington (Prof. David R. Williams)
      • Ph.D. 2008 The University of Alabama (Prof. Michael P. Jennings)

       

      Dr. Carrick's Curriculum Vitae 

      Bio

      Jesse D. Carrick was born in Murfreesboro, TN and spent his formative years on the family farm near Shelbyville, TN.  He attended Cascade High School, Wartrace, TN and graduated with an Honors diploma in 1998. Carrick attended Motlow State Community College and graduated with an A.S. in 2000. He was introduced to the art and science of chemical synthesis as an undergraduate student at Middle Tennessee State University with Prof. Norma K. Dunlap earning an ACS-certified B.S. in chemistry in 2002. Carrick then relocated to Indiana University, Bloomington where he contributed to efforts toward the total synthesis of the marine natural product amphidinolide C in the laboratory of Prof. David R. Williams, earning his M.S. in 2005.  Carrick completed his doctoral work at The University of Alabama in 2008 under the direction of Prof. Michael P. Jennings where he accomplished a formal synthesis of the marine natural product (−)-clavosolide a. 

      He obtained professional experience as a Senior Research Scientist in chemical development (process) at Albany Molecular Research Inc., in Albany, NY from 2009-10 and returned to academia as a Visiting Assistant Professor of Chemistry at Union College, Schenectady, NY (2010-11) where he initiated research in the area of organic synthesis with undergraduates. 

      Carrick accepted a tenure-track appointment as an Assistant Professor in the Department of Chemistry at Tennessee Technological University, Cookeville, TN in 2011, was tenured and promoted to Associate Professor in 2016, and promoted to Professor in 2021. Research in the Carrick group is currently focused in two distinct, but complementary student-training areas: Synthesis of heterocyclic complexants for chemoselective minor actinide separations, and  Total synthesis of biologically relevant natural products. 

      When not in the lab he enjoys studying American history, fishing, gardening, and drag racing.

    • Publications
      31.  Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Carrick, J. D.* A Hydrolytically Stable Complexant for Minor An Separation from Ln in Process Relevant Diluents.  Chemical Communications 2024, 60, 5642–5645. View Article
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      30.  Edirin, O. J.; Carrick, J. D.* Synthesis of Fused [1,2,3]-Triazoloheteroarenes via Intramolecular Azo Annulation of N-Tosylhydrazones Catalyzed by 1,8-Diazabicyclo[5.4.0]undec-7-ene.  Journal of Organic Chemistry 2024, 89, 7201–7209.  View Article
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      29.  Tedder, M. L.; Carrick, J. D.* A Synthetic Strategy for the Preparation of Alkoxy-Functionalized Bis-1,2,4-triazinyl-pyridines.  Journal of Heterocyclic Chemistry 2024, Early View.   View Article
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      28.  Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Joyner, N. A.; Mason, M. M.; Oliver, A. G.; Ensor, D. D.; Dixon, D. A.; Carrick, J. D.* Next Generation 3,3’-AlkoxyBTPs as Complexants for Minor Actinide Separation from Lanthanides:  A Comprehensive Separations, Spectroscopic, and DFT Study.  Inorganic Chemistry 2024, 63, 4819–4827. View Article
      061224_4
      27.  Agyei, E. A.; Carrick, J. D.* Synthetic Approach to the Construction of Unsymmetric Pyridyl-1,2,4-Triazine Complexants.  Tetrahedron 2024, 155, 133872.  DOI: View Article
      061224_5
      26. Fletcher, L. S.; Tedder, M. L.; Olayiwola, S. O.; Ensor, D. D.; Carrick, J. D.* Separation of 241Am3+ from 154Eu3+ from Simulated Spent Nuclear Fuel in Trifluoromethylphenyl Sulfone using 3,3’-butyloxy-bis-1,2,4-triazinyl-2,6-pyridine as a Potent Receptor. Solvent Extraction and Ion Exchange 2024, 42, 105–117.  View Article
      25. Agyei, E. A. and Carrick, J. D.* Metal-Free, Oxidative Condensation of Heteroaryl- and Aryl Carbaldehydes towards Functionalized Carbonitriles.  Chemistry Select 2023, 8, e202300866. View Article
      061224_7
      24. Xiao, Z.; Liu, J.; Liu, K.; Petridis, L.; Cai, C.; Cao, L.; Wang, G.; Chin, A.-L.; Cleveland, J. W.; Ikedionwu, M. O.; Carrick, J. D.; Smith, J. C.; Quarles, L. D.*  Small Molecule FGF23 Inhibitors Increase Serum Phosphate and Improve Skeletal Abnormalities in Hyp Mice.  Molecular Pharmacology 2022, 101, 408–421.  View Article
      23. Tedder, M. L.; Dzeagu, F. O.; Mason, M. M.; Dixon, D. A.; Carrick, J. D.*  Microwave-Assisted C-H Oxidation of Methylpyridylheteroarenes via a Kornblum-type Reaction. Tetrahedron 2022, 116, 132805,  DOI:  View Article  
      poster23
      22. Gulledge, Z. Z.; Duda, D. P.; Dixon, D. A.; Carrick, J. D.*  Microwave-Assisted, Metal- and Azide-Free Synthesis of Functionalized Heteroaryl-1,2,3-triazoles via Oxidative Cyclization of N-Tosylhydrazones and Anilines.  Journal of Organic Chemistry 2022, 87, 12632–12643,  View Article
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      21.  Gulledge, Z. Z.; Pinson, C. C.; Stovall, A. M.; Dzeagu, F. O.; Carrick, J. D.*  Chemoselective, Osmium-Free, Dihydroxylation / Oxidative Cleavage of Heteroaryl Isoprenes by a Contemporary Malaprade Reaction.  Organic and Biomolecular Chemistry 2022, 20, 7916–7922.  View Article
      poster21
       
      20.  Dzeagu, F. O.  and Carrick, J. D.*  Synthetic Access to Unsymmetric 1,3,4-oxadiazolyl Complexant Scaffolds via Intramolecular Oxidative Annulation of Arylhydrazones with Heteroaryl Carbaldehydes.  Journal of Organic Chemistry 2022, ASAP, 12/27/22  View Article
      poster20
      19.  Prediction of An(III)/Ln(III) Separation by 1,2,4-Triazinylpyridine Derivatives Marcos M. Mason, Caris Smith, Monica Vasiliu, Jesse D. Carrick, and David A. Dixon The Journal of Physical Chemistry A 2021 125 (30), 6529-6542 View Article
      poster19
      18.  Downs, R. P.; Xiao, Z.; Ikedionwu, M. O.; Cleveland, J. W.; Chin, A.-L.; Cafferty, A. E.; Quarles, L. D.; Carrick, J. D.*  Design and development of FGF-23 antagonists:  Definition of the pharmacophore and initial structure-activity relationships probed by synthetic analogues.  Bioorganic and Medicinal Chemistry 2021, 29, 115877.  DOI: 10.1016/j.bmc.2020.115877. View article.

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      17.  Waters, G. D.; Carrick, J. D. "Convergent access to bis-1,2,4-triazinyl-2,2’-bipyridines (BTBPs) and 2,2’-bipyridines via a Pd-catalyzed Ullman-type reaction." RSC Advances 2020, 10, 10807–10815. View Article
      Abstract pic
      16.  Gulledge, Z. Z.; Carrick, J. D.* Chemoselective BOC-deprotection of functionalized heteroarenes using an addition/elimination strategy.  European Journal of Organic Chemistry, 2020, 12, 1817–1822.  View Article Poster2
      15.  Gulledge, Z. Z.; Tedder, M. L.; Lyons, K. R.; Carrick, J. D.* Synthesis of tridentate indolyl pyridinyl [1,2,4] triazine Lewis basic complexants via Pd-catalyzed Suzuki-Miyaura cross-coupling.  ACS Omega, 2019, 4, 18855–18866.  View Article

      Poster3

      14.  Veerakanellore, G. B.; Smith, C. M.; Vasiliu, M.; Oliver, A. G.; Dixon, D. A.; Carrick, J. D.*  Synthesis of 1H-pyrazol-5-yl-pyridin-2-yl-[1,2,4]triazinyl soft-Lewis basic complexants via metal and oxidant free [3+2] dipolar cycloaddition of terminal ethynyl pyridines with tosylhydrazides.  Journal of Organic Chemistry 2019, 84, 14558–14570.  View Article

      Poster4

      13.  Chaudhuri, S.; Carrick, J. D.* Synthetic access to functionalized dipolarophiles of Lewis Basic Complexant Scaffolds through Sonogashira Cross-Coupling.  Journal of Organic Chemistry 2018, 83, 10261−10271, View Article

      Poster5

      12.  Smith, C. D.; Downs, R. P.; Carrick, J. D.; Dietz, M. L.* Determination of extractant solubility in ionic liquids by thermogravimetric analysis. Solvent Extraction and Ion Exchange 2018, 36, 304−314.  View Article
      11.  Lambert, A. E.; Carrick, J. D.* Diversification of 6-bromo-2-substituted pyridine derivatives via Suzuki-Miyaura cross-coupling.  Journal of Heterocyclic Chemistry 2018, 55, 1232−1239, View Article

      Poster7

      10.  Hill, T. G.; Chin, A.-L.; Tai, S.; Carrick, J. D.; Ensor, D. D.; Delmau, L. H.  Separation of americium from europium using 3,3’-dimethoxy-phenyl-bis-1,2,4-triazinyl-2,6-pyridine. Separation Science and Technology 2018, 53, 1848−1855, View Article
      9.  Tevepaugh, K. N.; Coonce, J. G.; Tai, S.; Delmau, L. H.; Carrick, J. D.; Ensor, D. D.  Chromatographic separation of americium from europium using bis-2,6-(5,6,7,8-tetrahydro-5,9,9-trimethyl-5,8-methano-1,2,4-benzotriazin-3-yl) pyridine.  Journal of Radioanalytical and Nuclear Chemistry 2017, 314(1), 371−376.  View Article
      8.  Cleveland, J. W.; Carrick, J. D.* Pd-catalyzed amination of functionalized 6-bromo-pyridinyl-1,2,4-triazine  complexant scaffolds.  European Journal of Organic Chemistry 2017, 2017(23) 3318−3327.  View Article

      Poster10

      7.  Downs, R. P.; Chin, A.-L.; Dean, K. M.; Carrick, J. D.* Synthesis of functionalized hemi-1,2,4-triazinyl-[2,2’]-bipyridines via telescoped condensation of [2,2']-bipyridinyl-6-carbonitrile. Journal of Heterocyclic Chemistry 2017, 54(6), 3008−3014.  View Article
      Poster11
      6.  Xiao, Z. S.; Riccardi, D.; Velazquez, H. A.; Chin, A.-L.; Yates, C. R.; Carrick, J. D.; Smith, J. C.; Baudry, J.; Quarles, L. D. Computationally identified novel chemical compounds that antagonize FGF-23.  Science Signaling 2016, 9(455), ra113-Cover Story.  View Article
      5.  Tai, S.; Marchi, S. V.; Carrick, J. D.* Efficient preparation of pyridinyl-1,2,4-triazines via telescoped condensation with diversely functionalized 1,2-dicarbonyls.  Journal of Heterocyclic Chemistry 2016, 53, 1138−1146.  View Article
      4.  Chin, A.-L.; Carrick, J. D.* Modular approaches to diversified soft Lewis basic complexants through Suzuki-Miyaura cross-coupling of bromoheteroarenes with organotrifluoroborates.  Journal of Organic Chemistry 2016, 81, 1106−1115.  View Article
      Poster14
      3.  Tevepaugh, K. N.; Carrick, J. D.; Tai, S.; Coonce, J. G.; Delmau, L. H.; Ensor, D. D.  Separation of americium from europium using camphor-bistriazinyl pyridine.  Solvent Extraction and Ion Exchange 2016, 34, 13−25.  View Article
      2.  Tai. S., Williams, N. J.; Carrick, J. D.*  Synthesis of bis-1,2,4-triazines via telescoped condensation of [1,10]-phenanthroline-2,9-dicarbonitrile with aromatic 1,2-dicarbonyls.  Journal of Heterocyclic Chemistry 2016, 53, 307−312.  View Article
      1.  Tai, S.; Marchi, S. V.; Dover, E. J.; Carrick, J. D.* Pd-catalyzed diamination of dibromo-1,2,4-triazinyl complexant scaffolds.  Journal of Organic Chemistry 2015, 80, 6275−6282.  View Article

      Poster17

     

    Current Group Members

     

    Teaching

    • CHEM 6210 Advanced Organic Chemistry

    • CHEM 3010 Organic Chemistry I

    • CHEM 3020 Organic Chemistry II

     

    Research Opportunities

    The Carrick group currently has open positions for postdoctoral, EVS Ph.D., M.S., and B.S. students for the 2024-2025 academic year.  Students with research interests in separation science broadly defined, as well as analytical, inorganic, and organic chemistry are particularly encouraged to contact Dr. Carrick at jcarrick@tntech.edu for additional information.  

     

    Carrick Group News

    • June 2024-Congratulations to Eric for successfully defending his M.S. thesis!  Eric will pursue a Ph.D. in chemistry at the University of Florida fall 2024.
    • June 2024-Congratulations to Orume for successfully defending his M.S. thesis!  Orume will begin his Ph.D. studies at the University of Arizona fall 2024.
    • June 2024-Congratulations to Victor for successfully defending his M.S. thesis!  Victor will matriculate to the University of Washington to begin working on his Ph.D. fall 2024.
    • May 2024-A collaborative project on the preliminary extraction efficacy of 3,3’-dioctyloxy BTP in a kerosene:isooctanol blend has been published in Chem. Commun.  https://doi.org/10.1039/D4CC00983E
    • May 2024-Orume’s project focusing on the construction of fused 1,2,3-pyridyl triazines has been accepted for publication in J. Org. Chem.  https://doi.org/10.1021/acs.joc.4c00627
    • May 2024-Mariah’s project describing a synthetic method for the preparation of symmetric alkoxy-BTPs has been published in J. Heterocycl. Chem.  https://doi.org/10.1002/jhet.4828
    • April 2024-Eric’s project aimed at the synthesis of unsymmetric BTP complexants for separations was published in Tetrahedron https://doi.org/10.1016/j.tet.2024.133872 
    • April 2024-Congratulations to Dr. Fletcher who accepted a staff scientist position at Oak Ridge National lab.
    • March 2024-A A Comprehensive Separations, Spectroscopic, and DFT Study on 3,3’-butyloxy BTP has been accepted for publication in Inorg. Chem.  https://doi.org/10.1021/acs. inorgchem.3c02061
    • February 2024-Evaluation of 3,3’-butyloxy BTP for 241Am3+ extraction in FS-13 has been disseminated in Slvt. Extr. Ion Exch.
    • June 2023-Congratulations to Meagan for successfully defending her M.S. thesis!
    • November 2022-Congratulations to Fortune for successfully defending her M.S. thesis and for beginning her first professional position at Eli Lilly and Co., Indianapolis, IN (Jan. ’23)!
    • November 2022-Congratulations to Dr. Carrick for receiving a Henry Dreyfus Teacher-Scholar Award.  www.dreyfus.org
    • May 2022-Congratulations to Connor for earning his B.S. in Mathematics
    • August 2021-Mariah matriculates to the Ph.D. program in Chemistry at Boston College and joins research group of Prof. P. Zhang
    • August 2021-Zac begins his first professional position in the medicinal chemistry division at Novartis Institutes for Biomedical Research, Boston, MA
    • June 2021-Congratulations to Mariah for successfully defending her M.S. thesis!
    •  June 2021-Congratulations to Zac for successfully defending his M.S. thesis!
    • May 2021-Congratulations to Gabrielle for earning her B.S. in Chemical Engineering and beginning her professional career at Eastman Chemical, Kingsport, TN

     

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